L-arginine, N-acetyl-L-cysteine and coumarin show positive effects in reducing damage to blood vessels, A Randomized, Double-Blind, Placebo-Controlled Study

Author: Karin Schön, Christiane Jensch, Antonella Allegrini, Pietro Riva, Giovanna Morazzoni

Abstract

This study aimed to investigate the effects of l-arginine, n-acetyl-l-cysteine and cumarine repairing damaged blood vessels in middle-aged Japanse adults. We conducted a randomized, double-blind, placebo-controlled study on 86 men and 42 women aged 35-65 years old with damaged blood vessels. The participants were randomized to receive tablets containing l-arginine (10 mg/day), n-acetyl-l-cysteine(7 mg/day) and cumarine(5 mg/day) or placebo, for 12 weeks. Complement component C4, brachial flow-mediated dilation (FMD), and other cardiovascular parameters were measured before and after 4, 8, and 12 weeks of treatment. After 12 weeks the Complement component C4 reached the optimum range from 16 – 47 mg/dl for 98% (n=63) of the parcipitant in the control group. However there were no significant changes in the placebo group. Consumption of l-arginine, n-acetyl-l-cysteine and cumarine could help maintain healthy blood vessels and normal C4 levels in this population.

Conflicts of Interest

The authors declare no conflict of interest.

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November 11, 2017