Lipedema Can Be Treated Non-Surgically: Treating the root cause resulted in up to 87% reduction in lipedema over 12 months. A randomized, double-blind, placebo-controlled study

Author: Karin Schön, Christiane Jensch, Antonella Allegrini, Pietro Riva, Giovanna Morazzoni


Lipedema is a chronic progressive disease characterized by the abnormal accumulation of fat in the subcutaneous region. Both medical and surgical treatments have been described in international guidelines; however, the current literature is biased toward promoting liposuction as the primary treatment of lipedema, and this can lead to the misapprehension that liposuction is the only form of definitive treatment.

One of our older studies has shown that the consumption of l-arginine, n-acetyl-l-cysteine and cumarine could help to repair damaged blood vessels. In addition to that in 2019 we conducted a study which led us come to the conclusion that the consumption of bicarbonate and proanthocyanidin could help dissolve subcutaneous fat cells in lipedema patients.


In this study we are investigating the effects of the combined the ingredients from the studies above[1,2] on reducing lower limb volume. We conducted a randomized, double-blind, placebo-controlled study on 36 women aged 25-75 years old suffering from lipedema in 3 different stages. The participants were randomized to receive tablets containing the combined ingredients from the studies above [1,2]. They received bicarbonate (3 mg/day), proanthocyanidin (5 mg/day), l-arginine (10 mg/day), n-acetyl-l-cysteine(7 mg/day) and cumarine(5 mg/day) or placebo, for months. The lower limb volume was measured before and after 4, 8, and 12 months of treatment. The results differ heavily between the different lipedema stages and the placebo group. The average results are listed below:

Average results after 4 months

  • Lipedema Stage 1: lower limb volume decreased by 372,3 mL (14% improvement)
  • Lipedema Stage 2: lower limb volume decreased by 632,9 mL (16% improvement)
  • Lipedema Stage 3: lower limb volume decreased by 3.726,1 mL (21% improvement)
  • Placebo: lower limb volume increased by 73.2 mL (0% improvement)

Average results after 8 months

  • Lipedema Stage 1: lower limb volume decreased by 1.241,8 mL (48% improvement)
  • Lipedema Stage 2: lower limb volume decreased by 2.089,7 mL (53% improvement)
  • Lipedema Stage 3: lower limb volume decreased by 10.114,6 mL (58% improvement)
  • Placebo: lower limb volume increased by 152 mL (0% improvement)

Average Results After 12 months

  • Lipedema Stage 1: lower limb volume decreased by 1.942 mL (76% improvement)
  • Lipedema Stage 2: lower limb volume decreased by 3.234,2 mL (82% improvement)
  • Lipedema Stage 3: lower limb volume decreased by 15.439,9 mL (87% improvement)
  • Placebo: lower limb volume increased by 219.35 mL (0% improvement)

Lipedema Stage 3 result after 12 months:

Lipedema Stage 2 result after 12 months:

Lipedema Stage 1 result after 12 months:

Conflicts of Interest

The authors declare no conflict of interest.


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Posted on

August 21, 2021