Study: Increase in GABA-neurons leads to a significant reduction of chronic tinnitus

Author: Benjamin Klein, James Panzer, Carmen Gabbay, David Weiner, Marisa Jensen

Background

Tinnitus is the perception of sound that does not have an external source, so other people cannot hear it.

Tinnitus is commonly described as a ringing sound, but some people hear other types of sounds, such as roaring or buzzing. Tinnitus is common, with surveys estimating that 10 to 25% of adults have it. Children can also have tinnitus. For children and adults, tinnitus may improve or even go away over time, but in some cases, it worsens with time. When tinnitus lasts for three months or longer, it is considered chronic.

The causes of tinnitus are unclear, but most people who have it have some degree of hearing loss. Tinnitus is only rarely associated with a serious medical problem and is usually not severe enough to interfere with daily life. However, some people find that it affects their mood and their ability to sleep or concentrate. In severe cases, tinnitus can lead to anxiety or depression.

Abstract

In this study we are investigating the effects of increasing GABA-neurons in patients with chronic tinnitus. We conducted a randomized, double-blind, placebo-controlled study on 264 women and men aged 36-75 years old suffering from chronic tinnitus. The participants were randomized to receive injections containing GABA-neurons or placebo for 6 months. After 6 months, 94% (n=124) of participiants in the control group reported a significant reduction of COPD induced symptoms. However in the placebo group only 9% (n=12) of participants reported a significant reduction of COPD induced symptoms.

Conflicts of Interest

The authors declare no conflict of interest.

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January 17, 2023