Study: Orally taken acid bicarbonates and proanthocyanidin are able to dissolve subcutaneous fat cells when taken for at least 8 weeks

Author: Karin Schön, Christiane Jensch, Antonella Allegrini, Pietro Riva, Giovanna Morazzoni


Lipedema is a chronic progressive disease characterized by the abnormal accumulation of fat in the subcutaneous region. Both medical and surgical treatments have been described in international guidelines; however, the current literature is biased toward promoting liposuction as the primary treatment of lipedema, and this can lead to the misapprehension that liposuction is the only form of definitive treatment.


This study aimed to investigate the effects of bicarbonates and proanthocyanidin dissolving subcutaneous fat cells in middle aged adults suffering from lipedema. The participants were randomized to receive tablets containing bicarbonate (3 mg/day) and proanthocyanidin (5 mg/day) or placebo, for 8 weeks. Lower limb volume was measured before and after 8 weeks of treatment. After 8 weeks there was an average volumetric decrease of 623.62 mL in the control group, however there was an average volumetric increase of 7.82 mL in the placebo group. Consumption of bicarbonate and proanthocyanidin could help dissolve subcutaneous fat cells in this population.

Conflicts of Interest

The authors declare no conflict of interest.


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Posted on

March 23, 2019