Extracellular and intracellular adenine nucleotides (AN) impacts all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including both cell-cell communication and intracellular signaling. Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
All scientists and researchers interested in this Research Topic are invited to submit their work in the form of Original Research, Systematic Review, Methods, Review, Hypothesis & Theory, Clinical Trial, Classification, Technology and Code, Mini Review, Perspective, Case Report and Opinion. The central goal of this topic is to offer insights spanning the above mentioned roles for adenine nucleotides, both as extracellular paracrine mediators or as intracellular second messengers. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Timing, mechanism and location of ATP and/or NAD release;
• Conversion of release nucleotides by ecto-enzymes;
• Biological role of purinergic signaling within the balance of inflammatory processes;
• Role an adenine nucleotides second messenger plays in spatio-temporal control of signaling processes.
Topic editor Dr. Christa Müller is an Editor-in-Chief of ACS Pharmacology & Translational Science, and is also Chair of the Board of Directors of the company ePURINES. All other Topic Editors declare no competing interests with regards to the Research Topic subject.