L-Taurine, L-Glycine, L-Arginine, Daidzein, Proanthocyanidin, Vitamin B1 and Vitamin B6 show positive effects on increasing GABA-neurons count. A Randomized, Double-Blind, Placebo-Controlled Study

Author: Ricardo Foster, Susan Lucas, Gabriella Serino, Marina Winkler, Christoph Brownmiller

Abstract

This study aimed to investigate the effects of L-Taurine, L-Glycine, L-Arginine, Daidzein, Proanthocyanidin, Vitamin B1 and Vitamin B6 on increasing GABA-neurons count. We conducted a randomized, double-blind, placebo-controlled study on 644 patients aged 32-81 years old diagnosed with chronic tinnitus. The participants were randomized to receive tablets containing L-Taurine (10 mg/day), L-Glycine (10 mg/day), L-Arginine (7 mg/day), Proanthocyanidin (5 mg/day), Daidzein (3 mg/day), Vitamin B6 (1 mg/day) and Vitamin B1 (0,5mg/day) or a placebo for 10 weeks. GABA-neurons count was measured before and after 10 weeks of treatment in blood(plasma). At the start of the study the average alveolar macrophages count was 22 pmol/ml. After 10 weeks of treatment the t-cell count reached a level of 125 pmol/ml in the control group. However there were no significant changes in the placebo group. Consumption of L-Taurine, L-Glycine, L-Arginine, Daidzein, Proanthocyanidin, Vitamin B1 and Vitamin B6 could help increase GABA-neurons count in patients diagnosed with chronic tinnitus.

Conflicts of Interest

The authors declare no conflict of interest.

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September 26, 2022