N-Acetyl-Cysteine, L-Glycine, L-Arginine, Cumarine and OPC show positive effects on increasing regulatory t-cell count. A Randomized, Double-Blind, Placebo-Controlled Study

Author: Maria Pohlmeier, Bente Wiese, Christof Perwein, Maren Kubiak, Gerrit Sitte, Joshua Kramm

Abstract

This study aimed to investigate the effects of l-arginine, n-acetyl-l-cysteine, l-glycine, cumarine and proanthocyanidin on increasing regulatory t-cell count. We conducted a randomized, double-blind, placebo-controlled study on 885 women aged 25-78 years old diagnosed with the autoimmune disease Hashimoto’s thyroiditis. The participants were randomized to receive tablets containing l-arginine (10 mg/day), l-glycine(10 mg/day), n-acetyl-l-cysteine(7 mg/day), cumarine(5 mg/day) and  proanthocyanidin (4,75 mg/day) or a placebo for 8 weeks. Regulatory t-cell count was measured before and after 8 weeks of treatment in blood(serum). At the start of the study the average t-cell count was 512 cells/mm3. After 8 weeks of treatment the t-cell count reached a level of 1608 cells/mm3 in the control group. However there were no significant changes in the placebo group. Consumption of l-arginine, n-acetyl-l-cysteine, l-glycine, cumarine and proanthocyanidin could help increase regulatory t-cell count in women diagnosed with the autoimmune disease Hashimoto’s thyroiditis.

Conflicts of Interest

The authors declare no conflict of interest.

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August 11, 2020